At age of 32, she left the convent in France and returned to Ireland. On her return, she was so disturbed by the plight of the poor, that, with the financial support of her family, she immediately set up a number of hedge schools in Cork to educate the Catholic children. She secretly gathered the children of the poor and taught them the catechism, reading, writing and mathematics.
As Nano spent her days with the children, they would tell her of their sick friends or family members. Nano began to visit the sick and the elderly after school, bringing them food, medicine and comfort. She often made visits late into the night, carrying her lamp among the alleyways. Because of this, Nano was fondly known as the ‘Lady of the Lantern’, going out to visit lonely and sick women in their homes, their garrets and their mud cabins, bringing them her compassionate presence and whatever help she could.
Between mid-1750 and 1769, she had opened seven schools, including two for boys, in Cork.